PATH 3610 Lecture Notes - Lecture 2: Haemophilia A, Exsanguination, Hepatocyte
16 Oct 2016
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Document Summary
Under normal conditions, proteins in the plasma are retained within the vasculature and there is little net movement of water and electrolytes into the tissues as blood passes through capillary beds! Balance is often disturbed by pathologic conditions that alter endothelial function, increase vascular pressure, or decrease plasma protein content => edema! Edema: accumulation of uid resulting from a net outward movement of water into extravascular spaces; may have minimal or profound effects depending on severity and location i. e. edema in lungs uid lls the alveoli, causing life-threatening hypoxia ! Hemostasis: process of blood clotting that prevents excessive bleeding after blood vessel damage! Hemorrhage: caused by inadequate hemostasis, can compromise regional tissue perfusion and when massive and rapid, can cause hypotension, shock, death! Hydrostatic pressure: the pressure of water, in uenced by the activity of the heart as a pump, the elasticity and recoil of blood vessels, the quantity of blood, etc.
