PATH 3610 Lecture Notes - Lecture 5: Wound Healing, Angiogenesis, Granulation Tissue

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Tissue repair: regeneration, healing & fibrosis: resolution (the ideal outcome) refers to the return to normal which will follow an uncomplicated acute inflammation regeneration: the replacement of necrotic parenchymal cells by new parenchymal cells of the same type. Repair: the restoration of tissue architecture and function after an injury; it occurs by two types of reactions, regeneration of the injured tissue and scar formation by the deposition of connective tissue. Both processes involve the proliferation of various cells and close interactions between cells and the ecm. Injury to these cells can only heal by scarring of the tissue - the. Functional cells of these tissues cannot be replaced: extensive injury to nervous or cardiac muscle tissue will thus lead to a functional deficit. What determines the rate of cell proliferation: the primary motivators for cell replication are proteins called cyclins, which interact with cyclin-dependent kinases within the nucleus and control the entry and progression of cells through the cell cycle.