PATH 3610 Lecture Notes - Lecture 7: Clonal Anergy, Immunoglobulin A, Mycobacterium
27 Mar 2018
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Document Summary
Opportunistic pathogens such as candida albican (a fungus in human body) will be easier to infect individuals with immunodeficiencies. Antigens that will result in vigorous immune response which the immune system mistaken as a threat (it is harmless otherwise) Can be classified as immediate or late-phase. Antigens are presented by cd4+ th2 cells with mhc2. B cell binds and be activated by the antigen. Differentiate into memory cells and plasma cells. Ige should normally be produced only when there is a parasitic infection. Ige bind to receptors on mast cells in tissues and basophils in circulation, cells get sensitized. Can be different types of ige corresponding to different epitopes on the antigen. Re-exposure of the allergen will be recognized by ige on mast/basophils. More than one antibody will bind and lead to degranulation and release substances such as histamine, heparin, protease, prostaglandin, chemokines etc. Result in allergic reaction, worst case will be anaphylaxis. Multi-organ allergic reaction usually caused by food.
