PSYC 1000 Lecture Notes - Lecture 24: Imipramine, Reuptake Inhibitor, Street Light

• School: University of Guelph
• Department: Psychology
• Course: PSYC 1000
• Professor: Dan Meegan

Document Summary

Depressed not simply low on a continuum of energy level. Basic process of depression that must be targeted thus target drugs should restore energy in depressed individuals. Without energizing non-depressed individuals candidate target drugs. Depressed: for some, it alleviated some symptoms. Overstimulation rare i. e. the perfect" target drug non-stimulant antidepressant. Listening to drugs" if a drug is effective at treating a disease, then the disease must be caused by those biological processes that are affected by the drug faulty reasoning is pneumonia caused by a lack of penicillin? no. Problems for amine hypothesis some antidepressants have no direct effect on amines time lag unexplained imipramine blocks reuptake in minutes/hours. Note: perhaps because it takes time to form new receptors upon new amines can act. Amine-depleting drugs usually do not produce depression. Why the amine hypothesis has persisted street lamp analogy. Once implicated, strong tendency to look at amine-targeting drugs. Analogy: other chemicals that affect amines imipramine is a dirty" drug.