PSYC 3030 Lecture Notes - Lecture 12: Tryptophan Hydroxylase, Essential Amino Acid, Monoamine Transporter

• School: University of Guelph
• Department: Psychology
• Course: PSYC 3030
• Professor: Boyer Winters

Document Summary

A serum factor in the gi tract capable of producing vasoconstriction. Sero (from serum) tonin (affecting vascular muscle tone) Found in serum gi tract of leeches, scorpions, lobsters. Lsd antagonizes the contractile effect of serotonin on smooth muscles. Monoamine: derived from an amino acid, converted via a multi step process, tryptophan. Synthesized in the 5-ht nerve cell bodies (cellular marker of 5ht neurons) and is transported to the nerve terminal by axonal transport. Try h activity is primarily regulated by neuronal firing through depolarization-induced phosphorylation by ca2+/calmodulin-dependent protein kinase ii (cam-k-11) Alad is not a marker, also involved in other nts. An essential amino acid derived from diet (animal and plant proteins) Transported into the brain by a special transport system, which is also targeted by other amino acids such as leucine, isoleucine, valine, phenylalamine, and tyrosine, (large neutral amino acids lnaa) A meal rich in proteins does not necessarily lead to high tryptophan brain concentration.