PSYC 3030 Lecture Notes - Lecture 20: Hypothermia, Xerostomia, Chemotherapy
12 Dec 2016
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Remapping for the potential of gene expression in rats. Derided as a gateway to harder drugs, not a lot of evidence for this. Marijuana-mixed of dried leaves and flowering tops (resin) Depot binding, kept from acting at receptors and from being metabolized. Smoking leads to thc being absorbed through the lungs. After peak levels drop (relatively quickly), metabolism and accumulation in the adipose tissues. Takes much more time for the metabolites to be eliminated from the body, because it accumulates in adipose tissue (and some of the original thc) T1/2 is 30 hours, but because of the depot binding, it can be found for weeks after (2-3 weeks) Inhibits voltage-gated ca2+ channels (inhibition of exocytosis), main mechanism. Agonists: thc, win 55, 212-2 (potent analgesic, synthetic) Antagonists: sr 141716 (rimonabant, anorectic agent) opposite effect of the munchies . Primary pre-synaptic: inhibitory (work on the calcium channels) Too lipid soluble to be stored in vesicles (made on demand), produced when needed.
