PSYC 3030 Lecture Notes - Lecture 3: Naloxone, Benzodiazepine, Amnesia
21 Feb 2014
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Document Summary
The same drug can have multiple actions and effects -> multiple ways of producing molecular changes. Specific effects: acts at neurotransmitter binding sites, modifies gating mechanism inside channel, direct interaction with channel protein, stimulates gs which is linked to adenylyl cyclase. Interacts with polar heads of phospholipids: disturbs the relationship of protein in membrane. Up-regulation of receptors and rebound increase in release. Extreme hyper excitability and massive ca2+ influx (rebound) Sedative effects: anxiety reduction, sedation, incoordination, memory impairment. Acute increase in endogenous opioid synthesis and release. Neuroadaptive decrease in gaba function without change in receptor number. Tolerance and signs of hyper excitability during withdrawal (seizures, tremors) Chronic effects show reduced firing rate, release, metabolism. Site of drug action is not always the site of drug effect. : miosis and mydriasis are controlled by different mechanisms. Atropine, a competitive antagonist for the muscarinic acetylcholine receptor, produces mydriasis because the pupils are no longer capable of constriction and dilation results.
