PSYC 4580 Lecture Notes - Lecture 4: Fatty Acid Amide Hydrolase, Social Anxiety Disorder, Anxiogenic
27 Sep 2017
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Chapter 3 cannabinoids & emotional regulation: anxiety, mood & depression, stress, ptsd, sleep disorders. Chronic use = increased anxiety and panic reactions: anxiety. Animal studies with thc = biphasic effect: low doses = reduced anxiety (anxiolytic, decreasing release of excitatory neurotransmitters, high doses (chronic) = produce/increase anxiety (anxiogenic, decreasing release of inhibitory neurotransmitters. Animal studies with cbd: moderate doses cbd = anxiolytic (reduced anxiety, high doses cbd = anxiolytic or no effect. Human studies with cbd: reduces anxiety in stimulated public speaking (social anxiety disorder, don"t get as anxious during the anticipation phase as those who took placebos. No published clinical trails for anxiety disorders and faah inhibitors. If given inhibitor faah: no drop in aea levels, no anxiety-like behaviour. Animal studies 2-ag: no anxiety-like behaviour (cbd might be an effective inhibitor, magl inhibitor reduces anxiety, especially in stressful conditions, less 2-ag = anxiety, increasing aea may be useful treatment for stress-related anxiety.
