BIOL 2410 Lecture Notes - Lecture 13: Axon Hillock, Signal Transduction, Schwaan

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Neuron physiology iv - electrical signalling in the neuron. In unmyelinated axons the action potential will propagate down the entire length of the axon. Ion channels are located all along the length of the axon. Signal of critical strength arrives at the axon hillock. Depolarization spreads forwards and back into adjacent segments. Negativity of the cell attracts positively charges sodium. Voltage gated sodium channels open in the area ahead of the action potential. Voltage gated sodium channels will not open in the area behind the action potential because they are inactivated. High concentration of voltage-gated sodium channels are located at the axon hillock. Ensures critical stimulus will lead to depolarization here. Voltage gated sodium and potassium channels have even distribution along the axon length. Myelin forms from concentric layers of glial cells bound together. Produced by oligodendrocytes in the cns and schwaan cells in the pns. Areas of unmyelinated axon are called nodes of ranvier.

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