BIOL 2420 Lecture Notes - Lecture 21: Fetal Circulation, Deoxygenation, Endothermic Process

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2420
• Professor: W.G.Anderson

Document Summary

P50 increased while ph decreases because the more protons the lower the ph - the more likely the bonds will be formed (positive to negative) More h+ = more co2 (more oxygen gets of oaded in the area: 2,3-diphopshoglycerate (dpg) Polyanionic (multiple negative) side-product of glycolysis in rbc. Glucose > 1,3 dpg > 3-pg > lactate + atp. This pathway can be regulated based on need. The space between the two beta-chains increase during the r < > t transition, allowing entry of dpg into this opening. R state - dpg cant t into the space inside hemoglobin, in t state there is enough room for dpg to t inside - will help of oad oxygen. Here, dpg can electrostatically interact with up to four residues (b1 val*, b2his*, B82lys, b143his*) of each beta-chain, this stabilizing the t-state protein. Maximum of 7 bonds - more bonds make the greater effect.