BIOL 2420 Lecture Notes - Lecture 33: Major Histocompatibility Complex, Mhc Class Ii, Antigen-Presenting Cell

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2420
• Professor: W.G.Anderson

Document Summary

Made by chance to see if one will match with the epitope of a pathogen. Each chain has a constant c and variable v region -> binds to antigen - mhc complex. Gene segments coding for the a and b chains are rearranged on dna level. Up to 109 different variations of alleles. 8-10 aa segment loaded on mhc class i platform. Very similar to apoptosis stimulated by natural killer cells: Granzymes that enter cells via the pore initiate apoptosis. Also, initiation of apoptosis via activation of fas a death receptor protein. Tcr & cd8 recognize ag-mhc i on a target cell. Activation and clonal selection (production of more speci c tc-cells) 13-18 aa segment of mhc class ii. Tcr & cd4 recognize a single ag-mhc ii on an apc. Autocrine: activation of the same cell type. Helper t-cells: th1- cells secrete ifn-y and il-12. Activation of macrophages and cytotoxic t-cells making these cells better killers.