ACB 330 Lecture Notes - Lecture 17: Laminin, Histogenesis, Extracellular Matrix
29 Mar 2018
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Use convergent extension and directions cell division lengthens te neural plate medial hinge point cells become wedge shaped: at this time epidermal cells push inwards. Apical constrictions drive the bending and folding of the neural plate. The neural plate cells then completely fold up and form the neural tube. Epithelial cells express e-cadherin (a cell adhesion protein). Neural plate (cid:272)ells tu(cid:396)(cid:374) off e0(cid:272)adhe(cid:396)i(cid:374) a(cid:374)d tu(cid:396)(cid:374) o(cid:374) (cid:862)n-cadhe(cid:396)i(cid:374)(cid:863) this leads to the neural tube dissociating from the epidermis. N-cadherin the stay stuck to the neural tube. Closing of tube starts in middle and zippers close to caudal and rostral ends. Spina bifida: lack of closure of posterior neuropore. Fetoprotein: abnormally high levels in amniotic fluid are indictive of open neural tube defects. Folic acid: prevent defects in neural tube closure: folate binding protein is expressed in converging neural folds: take your damn folic acid. The neural plate has different fates along the ant-post axis.
