ANBI 360.3 Lecture Notes - Lecture 28: Gm2 Gangliosidoses, Genetic Disorder, Epilepsy
20 Jun 2018
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LECTURE 28!
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dog genetics!
breeders are encourages to regularly test for health and genetic problems and are encouraged •
to openly share results of all such testing that are undertaken, they should also follow
recommended protocols for the control of genetic disease.!
!
dog & cat genetics!
single gene inheritance- some disorders!•
multifactorial inheritance- most disorders!•
chromosomal inheritance- few reported!•
!
!
GM2 Gangliosidosis- cat single gene disorder!
burmese cats!•
autosomal recessive!•
observed at 6-8 weeks of age!•
begins with mild tremors and leads to difficulty eating and lack of coordination!•
there is a DNA test available!•
!
multifactorial disorders!
many genes + environmental triggers!•
accounts for the vast majority of late onset inherited diseases!•
difficult to identify genes involved ( so not many DNA tests)!•
difficult to eradicate!•
weight "risk" and " burden"!•
risk= recurrence risk in offspring!◦
burden= perceived pain, discomfort, & cost of coping with the disorder!◦
!
example: Epilepsy!
multifactorial seizure disorder!•
more common in certain breeds, such as Belgian Shepard!•
in 2010, new paper suggests multiple genes!•
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Hip dysplasia !
shallow acetabulum!•
typically diagnosed by x-ray!•
more severe cases show symptoms at younger ages!•
hip dysplasia mating to minimize!
unless breeding excellent hips to excellent hip you will have then change to get hip ◦
dysplasia!
!
specialist at dog shows!
eye tests often available at shows!•
BAER hearing tests!•
help make tests by specialists more accessible to dog owners!•
also makes testing seem " the thing to do"!•
!
CHIC certification!
voluntary program organized by breed clubs to identify genetic disorders at high risk!•
