BMSC 200 Lecture 5: lecture 5

• School: U of S
• Department: Biomedical Sciences
• Course: BMSC 200
• Professor: Yangdong Wei

Document Summary

To be able to articulate how the structures of hemoglobin and myoglobin contribute to their unique biological functions. To be able to describe the various physiological signals which regulate hemoglobin(cid:1)s affinity for oxygen. To be able to describe the molecular mechanisms of allosteric regulation of hemoglobin. To be able to explain the molecular basis of sickle cell anemia and how it relates to malaria. Every cell in the body requires a constant supply of oxygen. To deliver oxygen from the lungs to the body. Solubility of oxygen in serum is too low for passive diffusion. None of the amino acid side chains are suited for reversible oxygen binding. Transition state metals have strong tendency to bind oxygen but also a strong tendency to produce damaging free radicals. Specialized oxygen binding proteins, hemoglobin and myoglobin, to achieve oxygen storage and delivery. The functions of many proteins involve their reversible interactions with other proteins and/or molecules.