TOX 300 Lecture Notes - Lecture 10: Liver Disease, Xenobiotic, Inbreeding
Document Summary
If the kidney is damaged there will be a limited ability to clear xeno from the body: physical (environmental) factors these can also influence toxicity, temperature important for cold-blooded animals. Isolation can increase the incidence of disease; they are lonely. *mechanism of repair to reverse toxic effects are very efficient and they rarely make mistakes. Biomedical applications where a more detailed understanding of the mechanisms underlying the toxicity of a particular xenobiotic is helpful. Targeting and selectively killing cells or tissues (e. g. in tumor therapy) Third step: risk assessment (to predict and prevent the problem: e. g. if you are a preg(cid:374)a(cid:374)t wo(cid:373)a(cid:374) do(cid:374)"t eat (cid:373)ore tha(cid:374) 1 (cid:272)a(cid:374) of tu(cid:374)a per (cid:373)o(cid:374)th since it contains methylmercury. Problems within the cell: enzymes get inhibited, cell become over activated, membranes lipids get destroyed, dna damage, etc. Step 4: inappropriate repair and adaptation toxicity. Overwhelms the ability of the repair mechanisms, increasing the probability of errors to occur.
