BIOL303 Lecture Notes - Lecture 3: Hedgehog Signaling Pathway, Lambda Phage, Smoothened
5 Dec 2016
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Document Summary
Endocrine: signals that act over long distances and act remotely. Juxacrine: membrane proteins of one cell interact with a receptor on an adjacent cell membrane. Delta/notch: delta is the ligand that binds to notch. Binding allows protease to cleave a portion of notch, which acts as a transcription factor. Autocrine: signals produced can act on the same cell that produced the signals. Paracrine: localized signalling that can induce changes in nearby cells, proximity increases response. Signal transduction: the reactions that occur following the binding of a ligand to its receptor. Paracrine factors bind to receptors, initiates signal transduction, causes change in transmembrane protein, this activates kinase activity which ultimately leads to gene expression or response. This allows ci protein to be made as a repressor which inhibits transcription. When hedgehog binds to patched, patched can not inhibit smoothened, and ci protein is made into an activator which activates transcription.
