CHEM120L Lecture Notes - Lecture 8: Transcription Factor Ii B, Fibronectin, Tata-Binding Protein
6 Nov 2017
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Molecular bio midterm questions section 8: describe the role of histone acetylation/deacetylation in regulation of transcription. Histones are tightly bound to dna as a result of the positively charged lysine group. Transcription factors regulate histone proteins so that they are either acetylated or deacetylated. This modification regulates transcription by either of the below: Deacetylation represses the gene activity: histone deacetyltransferases found in co-repressor complexes. Activators: co-activator proteins connect transcription factors with general transcription factors to assemble the initiation complex. Tf establish the spatial pattern in an organism (i. e. spinal column in vertebrates) during development. Tbp is a component of a position factor which allows, regardless of the rnap transcribing, each type of rnap to bind to its promoter. Sp1 protein is a transcription factor that binds directly to tata-less promoters on. Dna via c2h2 zinc fingers which recruits tfiid to the gc box and enhancing transcription.
