CHEM267L Lecture Notes - Lecture 1: Telomerase Reverse Transcriptase, Lab Report, Methoxy Group
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You must type directly into the answer boxes of the report template. Font or size-altered answer boxes will receive a mark of zero. Structures may be written by hand in pen. Pencil, erasable pen or white-out is not permitted. Please give a brief overview of this friedel-crafts alkylation reaction, including: the type of activating (or deactivating) groups on the aromatic ring; the specificity of the location of. The aromatic ring has two methoxy groups, which means that both groups are moderate activators. The substitution occurs ortho to both methoxy groups, in the clockwise direction, due to the methoxy groups favouring ortho over para. Lastly, the electrophile used in this reaction is t-butanol. substitution; and the electrophile used in this reaction. (1. 5 marks) Friedel-crafts alkylations are rarely used in synthetic chemistry because of several limitations. Two limitations of the friedel-crafts alkylation are the firstly, the benzene ring must be attacked by an alkyl halide.
