KIN408 Lecture Notes - Lecture 13: Dilated Cardiomyopathy, Congenital Heart Defect, Cardiac Muscle Cell
6 Aug 2019
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Document Summary
What is heart failure: the inability of the heart to develop enough pressure to maintain normal cardiac output and blood pressure. Therefore, blood flow and thus oxygen delivery to peripheral tissues and organs is impaired. Most apparent during physical activity: combination of structural, cellular, metabolic impairments that less to cardiac dysfunction, hf is a disease that has a spectrum of severity, a person can have systolic heart failure, diastolic hf or both. Heart failure risk factors: non-modifiable, age heart failure is the leading cause of hospitalization in people >65 years, genetics congenital heart disease is a defect in a structure of the heart (ex. Pathway of heart failure: cell death examples, myocardial infarction severely reduced/zero blood flow to areas in the heart (lv) which results in cell death, cad and hypertension induced cell death. Heart failure and changes to the pressure volume loop. Increase edv is beneficial because increase preload (frank- starling law).
