KIN408 Lecture Notes - Lecture 17: Vladimir Demikhov, Christiaan Barnard, Human Leukocyte Antigen
6 Aug 2019
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Document Summary
A historical perspective research era: alexis carrel during the late 1800"s, early 1900"s, 1902 attempted the first heterotopic heart transplant, 1912 won the nobel prize for medicine and. Physiology for his advances in surgical techniques: developed vascular anastomosis, heterotopic organ transplantation, 1933 the mayo clinic mann and colleagues. 5 successful and survived between 6 and 21 days post-op: december 3, 1967 dr. christiaan barnard, performed the first successful (albeit short lived) heart transplant in a human from a human donor. Recipient dies 18 days postoperative due to pneumonia: 1968 surgeons at baylor university, began looking at blood-group compatibility, lymphocyte crossmatch, and developed a matching grade system. 7 of 10 transplant patients were alive 4. 5 months after transplantation: modern era, seven-year survival rates for heart transplant recipients transplanted between 1988-1994, 1995-2000, and 2000-2007 were 59%, 62% and 65%, respectively. Matching donors to recipients: blood type o, a, b, ab.
