NE224 Lecture Notes - Lecture 11: Cell Nucleus, Pyrimidine, Ribose
9 Oct 2014
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Nucleic acids are linear polymers of nucleotides monomers (i) ribonucleotides (ribose) (ii) deoxyribonucleotides (2"deoxyribose) Each nucleotide consists of base, sugar and phosphate: The bases can be purines (a,g) or pyrimidines (c,t/u): Nucleotides are linked via phosphodiester linkages between the c5" carbon of one ribose and the. Dna is much less susceptible to hydrolysis than rna, which hydrolyzes relatively easily due to base catalyzed attack by the c2"oh on the phosphate! Dna is more stable for storage of genetic information, rna can form more complicated structures due to 2"oh (more on this later ) 1 schematic presentation of structural motifs of dna. a: sticky ends, b: duplex, c: hairpin, d: stem structure, e: g-quadruplex, f: crossover region. Dna can form higher order structures: owing to fewer bases. + geometrical constraints, these are generally simpler than for proteins; multiple chains can be involved. Moritz k. beissenhirtz and itamar willner* dna-based machines org.
