BIOC 202 Lecture Notes - Lecture 30: Pyruvate Carboxylase, Phosphoenolpyruvate Carboxykinase, Dihydroxyacetone Phosphate
Document Summary
The process of generating glucose from non-carbohydrate precursors: occurs primarily in the liver (and a little in the kidneys) to maintain blood glucose levels. Lactate/pyruvate: lactate + nad+ pyruvate + nadh + h, during times of high muscle activity, glucose is fermented into lactate. The liver can take it up, convert it to pyruvate, and then back to glucose. How this helps: oxaloacetate is in the second step of gluconeogenesis. Therefore, any krebs cycle intermediate can be used to make more oxaloacetate except. Why you can"t use acetyl coa (and the fatty acids which are broken down into acetyl coa): Acetyl coa can"t be converted back to pyruvate. Acetyl coa can"t yield a net gain of oxaloacetate fats (with the exception of glycerol) can"t make sugars but sugars can make fat: glycerol (the backbone of a triacyl glycerol) can be converted to dhap. Gluconeogenesis is almost the reversal of glycolysis, but not quite.
