BIOC 202 Lecture Notes - Lecture 5: Isocitrate Dehydrogenase, Succinate Dehydrogenase, Malate Dehydrogenase
Document Summary
See slide for simplified version of krebs cycle. Also known as the citric acid cycle and the tricarboxylic acid cycle (tca cycle) These electrons can be used in oxidative phosphorylation to generate atp. The krebs cycle is also a source of many biological precursors (fig. The 8 reactions of the krebs cycle: citrate synthase forms citrate by binding oxaloacetate to acetyl coa, going from a c4 molecule to a c6. Can look at it as 2 steps: aldol condensation to form citryl coa, hydrolysis of citryl coa to form citrate and coash. Synthase: an enzyme catalyzing a synthetic reaction in which. 2 units are joined without the direct participation of atp: this reaction used the hydrolysis of the thioester to drive the reaction. Isocitrate is oxidized/decarboxylated to -ketoglutarate by isocitrate dehydrogenase. Isocitrate is oxidized to oxalosuccinate, generating nadh a: oxalosuccinate is decarboxylated to -ketoglutarate (spontaneously)
