BIOC 302 Lecture Notes - Lecture 1: Anomer, Pentose, Enol
Document Summary
Prime is used to distinguish between the purine/pyrimidine ring and the pentose ring. 1" carbon = the anomeric carbon links the chains together. Bond between carbohydrates = glycosidic bond: -n-glycosidic bond the link that is always between all nucleic acids the bond goes up/out of the page . Reaction required to make the bond between the pentose and the purine/pyrimidine = condensation. Phosphate bond: pka = ~1 negative under physiological conditions. Tautomerization lone pair nitrogen and keto group keto goes to enol. 5" is different than the other 4 achiral. The sugar in ribonucelosides is d-ribose: nucleoside no phosphate, nucleotide phosphate. The sugar in deoxyribonucleosides is a derivative of this: 2-deoxy-d-ribose (no hydroxyl group in the 2" position) To switch from linear to ring form, you form an ether (alcohol ether: ketone alcohol, aldehyde + alcohol hemi-acetal.
