BIOL 112 Lecture 10: BIOL 112- Nucleic Acids- DNA structure, assembly and organization
59
BIOL 112 Full Course Notes
Verified Note
59 documents
Document Summary
Describe and recognize the structural components of nucleic acids, including the monomers, the directionality, and the reason for the directionality. Identify key structural differences between dna and rna. Label a schematic diagram of double stranded dna to show the 3" and 5" ends, including the functional group found at each 3" and 5" position. Know and apply the chargaff"s (watson & crick) base pair rules. Major groove, minor groove - due to the geometry of how the bases pair. Angle of base interaction is tilted, distorts structure. 2 purines: no room for bases0 there can be h-bonds but shape will bulge out. 2 pyrimidines: in order to h bond the molecules will tilt inwards to get close enough stacking interactions interrupted b/c structure is not flat = too much. Watson-crick base pairs all have the same general geometry: Regular flat stacking interactions between bases above and below. Most important factor: only certain purine-pyrimidine base pairs have the same geometries.
