BIOL 336 Lecture Notes - Lecture 12: Allele Frequency, Genetic Drift, Allele

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24 Apr 2015
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Outline for lecture 12 migration and combined mechanisms. Founder effect: differences in allele frequencies between populations due to the very small number of founding individuals (a new population founded from old one) Bottleneck: a period of very small size in population history (the effect of genetic drift is increased) Fe and bn cause a loss of variation. They don"t lead to high frequencies of rare alleles but we notice when they do. Mutation typically adds deleterious alleles (can improve an allele but generally not) - the possibility of mutation repairing a broken" allele is quite low - many ways to break a working copy than to repair a damaged copy. Rate at which mutations is added is proportional to (1-q) We use minus because it"s a deleterious allele. W = mean fitness of population (if mutant is rare you can pretty much ignore it and assume w~ 1)

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