CAPS 390 Lecture Notes - Lecture 21: Autocrine Signalling, Amine, Hydrophile
15 Dec 2016
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Autocrine: cell secretes a hormone that binds to receptors on the same cell. Paracrine: cell secretes a hormone that targets other cells, but very near. Endocrine: hormone travels a great distance, targeting a vast amount of cell and organs. Composed of amino acids arranged as a complex chain. Peptides are hydrophilic which can react with water. Monoamines: composed of one amino group connected to an aromatic ring. Most amines are water soluble and lipid soluble. Composed of a core of four fused carbon rings and one side chain. The functional groups (hydroxyl groups) attached to rings determine activity. It is bound to transport proteins in blood. Lipid soluble means hormones are free to cross the blood-brain-barrier. So they must regulate forms of functions within the entire cns. Usually these hormones must bin to carrier plasma proteins to ensure solubility in the aqueous environment of the plasma within blood.
