CAPS 390 Lecture Notes - Lecture 23: Autocrine Signalling, Amine, Adrenocorticotropic Hormone
18 Nov 2015
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Bind to carrier plasma proteins to ensure solubility in the blood. Lecture 23 summary: dr. viau, oct 27, 2014. Note: lipid soluble hormones cannot freely move around in the blood/plasma because they are not water soluble. Therefore, they are bound to water soluble carrier plasma proteins. Cortisol for example is bound to cortisol-binding globulin in the blood. The hormones are then transported down axons that pass through the median eminence: the hormones are then stored in vesicles in axon terminals (=herring bodies) in the posterior pituitary. Upon appropriate stimulation, the hormones are released by exocytosis and are then able to move into nearby capillaries that drain into the hypophyseal vein for distribution to the tissues of the body. Therefore, the posterior pituitary is neural in nature: indirect pathway: "releasing" peptide hormones are synthesized in nerve cell bodies in the hypothalamus (ie. within hypothalamic nuclei).
