CAPS 390 Lecture Notes - Lecture 21: Natural Killer Cell, Perforin, Complement System
18 Nov 2015
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Lecture 21 lymphoid system, oct 22, 2014 (roskelley) Lymphoid/immune system are responsible for defense against foreign invaders. Binding of tlr to a pathogenic molecule stimulates macrophage/neutrophil to phagocytosis and destroy pathogen. Initiated by very strong innate immunity responses. Dendritic/monocytic cells (antigen presenting cells apc) that present antigen to lymphocytes (often t- cells) also exits blood by diapedesis. Acquired immunity; slower response (days to weeks) Responds to specific antigens (molecular epitopes) Mediated by b and t lymphocytes (cells) Na ve, immunocompetent b cells (lymphocytes) produced in bone marrow. Na ve, immunocompetent t cells (lymphocytes) produced in bone marrow and the thymus. Initial development in the bone marrow (bm) Proliferate and generate different clones of b- lymphoblasts (remain in bm) T- lymphoblasts generated in bm migrate to thymus via blood vascular system. Differentiate into pre- t- cells; each pre- t- cell clone expresses a specific t- cell receptor (tcr) that recognizes a single antigen with high specificity.
