PHAR 430 Lecture Notes - Lecture 2: Competitive Inhibition, Theobromine, Cadaverine
Document Summary
Phase i enzymes: name four phase i enzymes and describe, using diagrams or equations, the reactions they catalyze, list the cofactors (if any) involved in reactions catalyzed by each of the enzymes named above (in objective 1). Just know that enzymes need cofactors to work: list the substrates of each of the enzymes named above (in objective 1). Should be able to estimate what the drug is going to be metabolized by: describe the tissue and subcellular location of each of the enzymes named above (in objective 1), along with other important properties of the enzymes. Do(cid:374)"t a(cid:272)tuall(cid:455) (cid:373)e(cid:373)o(cid:396)ize the lo(cid:272)atio(cid:374)s this is to provide context: given the chemical structure of a drug and the name of the phase 1 enzyme involved in its biotransformation, draw one possible metabolite of the drug. Add/expose polar functional groups (oh, nh2, sh, cooh) Oxidation catalyzed by oxidases or oxygenases. Hydrolysis catalyzed by hydrolases and esterases/amidases.
