PHAR 454 Lecture 9: 9. Diarrhea and Diaper Rash

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Learning objectives: diaper rash: describe the pathophysiology of diaper dermatitis, describe the treatment approach for diaper dermatitis, given a patient with diaper dermatitis, be able to provide pharmacologic and nonpharmacologic recommendations and justify them. Ave child < 5 years old: 2. 2 episodes/year. Usually mild and brief < 1 week duration. Viral (75-90%: rotavirus most common infectious cause of diarrhea in pediatrics. Noninfectious cause: changes in diet, lactose intolerance, antibiotics. Contraindications: protracted vomiting despite small, frequent intake, shock- like symptoms, impaired consciousness, paralytic ileus, monosaccharide malabsorption. Three elements in oral rehydration therapy: rehydration, replacement of ongoing losses, maintenance. Continue to breast/formula feed, ors in between. High osmolarity, low electrolytes, high carbs may exacerbate (osmotic) Loperamide may reduce duration of diarrhea by 0. 8 days for children > 3 years olf. Loperamide: toxic megacolon, lethargy, respiratory depression, necrotising enterocolitis. Affects up to 50% of at-risk pediatric population. Types: irritant, candida, allergic do(cid:374)"t (cid:374)eed to differentiate.

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