PHAR 315 Lecture Notes - Lecture 12: Horse Length, Bioavailability
Document Summary
Kel x vd x cp describes eliminaion ddb dt. The diferenial equaion is useful to describe the concentraion ime curve before integraion is necessary: iniially: dg >> (vd x cp) The value of vd x dcp/dt is positive, so cp (plasma concentraion) increases: over ime: dg decreases, cp increases simultaneously therefore there is an instant where: Ka x dg = kel x vd x cp so vd x dcp/dt = 0 this is the peak in the curve: later imes: dg approaches 0. Vd x dcp/dt becomes negative, so cp decreases. Using the integrated equaion to calculate the cp line: start with dg = dg x e-kaxt, subsitute (f x dose) for xg0 plasma-concentraion. 1: this equaion is bi-exponenial the constant is ploted against the diference between two. Single oral dosing exponenials: when ploing the exponenials, this is the graph: If we muliply both curves by the constant: the resuling plot is cp vs ime:
