PHAR 315 Lecture Notes - Lecture 13: Loading Dose
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Recall that the calculaion for cp following a single oral dose is: Convert this equaion to give an equaion for cp any ime ater n doses (similar to muliple iv bolus dose equaion): But we can simplify this by assuming that subsequent doses are given. After the cp has peaked (i. e. ater the absorpion phase is complete) means that e-kaxt is approaching zero: To study drug accumulaion, we observe the raio between the: minimum concentraion at steady state (cpmin, the concentraion one dosing interval (t) ater the irst dose (cpt. This is the same equaion as for the iv bolus: therefore we can calculate the loading dose as: This only works if each dose aterwards is given. After the absorpion phase is complete (i. e. ater cpmax) We can simplify the cpmin equaion at css: at css, ka >>> kel, so ka kel ka, therefore ka ka kel. So ater muliple oral doses (with a constant dose and constant dosing interval):
