PHAR 462 Lecture Notes - Lecture 5: Cox-2 Inhibitor, Diclofenac, Ibuprofen
8 Apr 2017
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Assess, triage and make a working diagnosis for a patient presenting with pain. Discuss prevalence, risk factors, signs and symptoms for the conditions discussed in lecture. Identify brand names, active ingredients, dosage forms, strengths, dosing and duration and to know the drug schedules as discussed in lecture. Formulate appropriate, evidence-based, patient specific treatment and/or prevention plans than include: goals of therapy, list of alternatives (drug and non drug, evidence-based recommendation, dose regimen, outcomes, counselling points, monitoring points. Meta-analyses of 280 trials (nsaid vs placebo; 124 513 participants) and 474 trials (nsaid vs. Nsaid; 229 296 participants: parti(cid:272)ipants: mean age 61 yo; 66% female; 79% caucasian; relatively healthy; 80% using nsaid for oa or ra, mai(cid:374) out(cid:272)o(cid:373)es: (cid:373)ajor vas(cid:272)ular eve(cid:374)ts ((cid:374)o(cid:374)-fatal mi, nonfatal stroke, vascular death); major coronary events (nonfatal. Mi or coronary death); stroke; mortality; heart failure; upper gi complications (perforation, obstruction, bleed) [increased risk vs. placebo (or a few cases vs. no nsaid)]
