PHRM 100 Lecture Notes - Lecture 6: Therapeutic Drug Monitoring, Psychiatric Medication, Chemotherapy
Document Summary
Definition : what the body does to the drug (adme & elimination) May be affected by drug, dose, frequency. Definition : application of pk principles to the safe and effective therapeutic management of drugs in an individual patient. Optimization of drug therapy for individual patients (dosage adjustment) Often done for medications with narrow ti. Purpose : to ensure safe and effective dosage regimens (through application of pk principles) and determination of plasma drug concentration. Note: monitoring needs to be done at steady-state (5 half lives) Plasma drug concentration is proportional to tissue drug concentration (reflective) Wide interpatient pk variability (disease state or patient factor) Pharmacological response of drug cannot be easily assessed. Antibiotics, immunosuppressants, respiratory medications, anti-seizure medications, chemotherapy, cardiac medications, psychiatric medication. Measure serum conc and see if its within therapeutic range or need adjustment. Decision to treat (determine best drug indicated for condition) Interpretation (does it make sense, is it what we expect)
