PHRM 100 Lecture Notes - Lecture 1: Medicinal Chemistry, Protein Folding, Protonation
Document Summary
The drug"s journey and the properties of atoms. Medicinal chemistry : relates the structure of a molecule to its action as a drug at the molecular level. Pharmacology : study of the drug in the body. Pharmacodynamics : study of effects of a drug on biological system. Pharmacokinetics : study of effects of the biological system on the drug (adme-tox) Today, we have target validation (initial part of drug development accelerated) Therapeutic targets (cause of disease) can be determined. Isolate proteins and receptors to see how they influence things. Drug discovery bottleneck: 90% failures rate at drug candidate-early phase 1/2 trials. Drugs derived from herbal medicines natural products (plant, bacteria, fungal, marine ) Nature uses physicochemical properties to create intention . Too much information can"t tell interactions accurately ribbon models usually used. Complementary components in drugs interact with proteins (receptor). Physical forces involved in protein folding and protein-drug interactions : Ionic (aka salt bridge; extreme case of h-bond)
