PHRM 211 Lecture Notes - Lecture 9: Vascular Resistance, Carboxypeptidase A, Tetrahedral Carbonyl Addition Compound
Document Summary
An elevation of arterial bp above a defined normal value (differs with sex & age) Most common modifiable risk factor for cvd. A function of the amount of blood pumped by the heart (cardiac output) & ease with which blood flows through the peripheral vasculature (total peripheral resistance) Risk of cv events (e. g. mi, stroke, heart failure, end-stage renal disease) can be greatly reduced by lowering bp by decreasing tpr and co through pharmaceutical intervention. Angiotensin-converting enzyme (ace) : found principally on endothelial cells lining the vasculature (i. e. in contact with blood) Angiotensin ii : potent vasoconstrictor; significant effect on sodium & fluid retention. Belongs to a metalloproteinase family of enzymes that cleave dipeptides from the. C-terminal ends of several endogenous peptides including angiotensin i (activating) and bradykinin (inactivating) Ace substrates must be: a tripeptide & contain a. Ace will not cleave peptides with proline as the penultimate residue explains why angiotensin ii resists ace cleavage.
