PHRM 211 Lecture Notes - Lecture 9: Orthostatic Hypotension, H1 Antagonist, Trazodone
Document Summary
Inhibits serotonin reuptake transporter (at higher doses, > 150 mg ) Does not alter the proportion of rem sleep. Auc is directly proportional to oral dosage (25-100 mg) May interact with other serotonergic agents serotonin syndrome. Excreted mainly by kidney t1/2: 6 h (parent drug), 13 h (metabolites) Note: lead to high discontinuation rates in clinical trials. Classified as a noradrenergic and specific serotonergic antidepressant (nassa). Used to manage symptoms of depression accompanied by anxiety or insomnia. Does not inhibit 5ht, na or da reuptake transporter, has no 5ht 2 agonist actions. Eliminated predominantly via kidney t1/2: 37 h (females), 26 h (males) Unlikely to cause sx of serotonin toxicity (mirtazapine blocks 5ht 2a receptors) Does not cause any cardiotoxic actions at hypnotic doses. Hormone synthesized by the pineal gland from tryptophan. Thought to regulate sleep-wake cycles and circadian rhythms. Acts on m1 and m2 receptors in hypothalamus to adjust/control circadian rhythm.
