PHRM 211 Lecture Notes - Lecture 12: Sleep Disorder, Paracetamol, Nonsteroidal Anti-Inflammatory Drug
Document Summary
Pharmacology review of pain medications (part 1) Many forms (e. g. arthritis, back/headache, neuropathic pain, unknown origin) Affects personality and behavior (depression is common) Opioids, nsaids, and acetaminophen are useful in managing acute pain. How do morphine and other opioids produce analgesia? (fyi slides 6-16) Women experience more pain and require more morphine to achieve the same level of analgesia. One theory: anatomical and physiological differences in the pag. Opioids are often not very effective in managing chronic pain. Effect of morphine on stt neuron excitability in. Morphine"s action (iv) on stt neurons in response to mechanical & thermal stimuli was significantly attenuated in diabetic rats. Morphine reduces pinch response by 75% in normal animals (control) and only 10% in diabetic animals. Other, at the site of stt neuron. Increased pain sensitivity and overall pain following opioid analgesics taken over time following increased dosing. Distinct from tolerance: increasing the dose pain. Leads to nmda receptor activation, glutamate transporter inhibition more.
