PHRM 211 Lecture Notes - Lecture 22: Pars Compacta, Substantia Nigra, Basal Ganglia
Document Summary
Neurofilament proteins and ubiquitin are other important constituents of lbs. Loss of pigmentation in the substantia nigra (pars compacta) Lewy bodies (inclusion) present in basal ganglia neurons. Primary constituent of lbs is -synuclein (presynaptic protein) function unknown. Evidence growing that improper protein folding and degradation play a role in lb formation and cell death. Major site of cell death in pd : substantia nigra pars compacta (snc) Impact of loss of da on function of the basal ganglia. May initially present with paresthesias and mild tremor. Diagnosis may take some time as symptoms evolve. Idiopathic pd (85%) includes relatively rare genetic forms. Falls at presentation and early in the disease. Rapid progression to h&y stage 3 in three years. Dysautonomia (urinary urgency/incontinence, fecal incontinence, urinary retention, persistent erectile failure, orthostatic hypotension) 2/4 of the cardinal signs (one of which must be tremor or bradykinesis )
