PHRM 221 Lecture Notes - Lecture 16: Ulcerative Colitis, Inflammatory Bowel Disease, Gut Flora
Document Summary
Week 16: nutrition for gi disorders (part 1) Optimal nutrition status is the balance between nutrient intake and nutrient requirements . To restore and maintain optimal nutrition status by: Managing reduced tolerance to a nutrient and food component. A group of heterogeneous inflammatory disorders of the git. Two main phenotypes: crohn"s disease (cd), ulcerative colitis (uc) Tissue inflammation cytokine response to various possible antigenic stimuli (e. g. pathogenic bacteria) Inflammation that involves all layers of the intestinal tract; any part of the git in a segmental manner. Symptoms: diarrhea, abscesses, fistulas, oxalate kidney stones, fever, arthralgia, cramping, pain, nausea, vomiting. Restricted to the colon , onset at the rectum may progress in a contiguous manner upwards , along the git, inflammation restricted to mucosa and submucosa. Bloody diarrhea, luminal edema, ulceration, tissue fibrosis, fever, arthralgia, cramping, pain. Malabsorption especially in cd of vitamins a, b12; zinc & magnesium. Loss of appetite, decreased dietary intake (e. g. energy, calcium)
