PHRM 311 Lecture Notes - Lecture 4: Methyldopa, Isotretinoin, Dialectical Behavior Therapy
Document Summary
An abnormality in the receptors for monoamine nts leads to depression. Drugs that tend to deplete biogenic amines produce depressive states in normal individuals. Drugs that increase biogenic amine activity will alleviate depression. The biogenic amines of interest: 5-ht, na, da (also has a role in depression) Changes in brain function and structure in mdd. The following brain structures are implicated in normal regulation of affective behavior: The figure (right) schematizes how mdd affects dynamic connectivity among brain regions involved in regulating mood and stress responses. Normal reciprocal connected feedback is highlighted by thick black arrows . In depressed brain, disrupted ( red wiggly line ) connectivity occurs and leads to. Hyperactivity in frontal ( yellow ovals, e. g. vmpc, lopfc ) cortical areas. Leaving limbic areas (pink oval) to augment hypothalamic ( light orange oval ) centers. Blood flow studies in mdd brains show hyperactive vmpfc & lopfc underlying in pain, anxiety, tension.
