PHRM 311 Lecture Notes - Lecture 5: Prostaglandin E2, Psychoactive Drug, Burping
Document Summary
Nhps for depression and anxiety (part 2) Epidemiologic studies show a correlation between n-3 fa (omega -3 fas) intake in the diet and a low incidence of depression. N-3 fa deficiencies reported in people with a wide range of mental disorders. N-3 fatty acids impact cell membrane integrity and fluidity (cell communication) 26 rcts (25 vs placebo, 1 vs antidepressants) Only included pts with mdd or unipolar dd. Smd (-0. 3, small/modest effect ) = reduction of -2. 1 on ham-d; high heterogeneity. No difference in remission rates or qol. Do not have sufficient high quality evidence to determine effects of 3-polyunsaturated fatty acids as a treatment for mdd. 1 rct with n>50: not better than placebo plus sertraline. 4 rct with n<40: all trials showed significant benefit with augmentation. Most studied: 1-4 g epa + dha daily (epa>60%) Approximately 1 g of epa/dha in one serving of fish (100 g or 3. 5 ou)
