PHRM 311 Lecture Notes - Lecture 3: Phenelzine, Mirtazapine, Citalopram
Document Summary
In the case of a reversible inhibitor of mao. 1) (cid:1006)) the ne released by tyramine can displace the rima (cid:1007)) allowing for normal destruc(cid:415)on of the extra ne. Ne can displace the binding of rima o mao. Mao, now devoid of its inhibitor, can catabolize ne and thus prevent the dangerous accumula(cid:415)on of ne. Claimed to be as e ec(cid:415)ve as tca therapeu(cid:415)cally. Less poten(cid:415)al for interac(cid:415)on with (cid:1009)-ht uptake blockers (?) O(cid:332)en referred to as special k or a horse tranquilizer . Used previously as a dissocia(cid:415)ve anesthe(cid:415)c agent in humans and in veterinary anesthesiology. Produces marked analgesia via its nmda blocking ac(cid:415)ons. Recent studies show its usefulness in producing marked an(cid:415)depressive ac(cid:415)ons. Depressive sx are rapidly and robustly improved when administered at sub-anesthe(cid:415)c doses (0. (cid:1009)(cid:3376)mg/kg iv over a (cid:1008)0 min period) Onset of an(cid:415)depressive ac(cid:415)on occurred within (cid:1008)0 min and lasted up to 1(cid:1008) days. P(cid:396)(cid:381)(cid:393)(cid:381)(cid:400)ed (cid:373)echa(cid:374)i(cid:400)(cid:373) : through its nmda blocking ac(cid:415)ons.
