PHRM 311 Lecture Notes - Lecture 21: Acamprosate, Cannabinoid Receptor, Headache
Document Summary
Consumed amount of alcohol per drinking day : . Return to any drinking: no statistically significant difference. Return to heavy drinking: no statistically significant difference. Relapse to heavy drinking: no statistically significant difference. Limited evidence but appears more effective than placebo. Higher doses (1800 mg/d) more effective than lower doses (900 mg/d) Gabapentin + naltrexone even more effective than either alone in one rct. Used for anxiety disorders, neuropathic pain conditions, acute alcohol withdrawal. Caution with risk of diversion/misuse, risk of confusion and falls in elderly/frail. Use limited by adverse effects (e. g. paresthesia, dysgeusia, anorexia, difficulty with. Gradual titration over 5-8 weeks is recommended concentration, nervousness, dizziness, pruritis) Reaction : sweating, headache, dyspnea, hypotension, flushing, tachycardia, palpitations, nausea, vomiting. Can occur if alcohol is consumed for up to 2 weeks after dose. Used for decades but not many well-controlled studies.
