PHRM 311 Lecture Notes - Aprepitant, Enterochromaffin Cell, Atropine
Document Summary
Pharmacology of the enteric nervous system (part 1) Found in the walls of the entire git from the oesophagus to the anus. A network of ~100 million neurons (similar to the number in the spinal cord) Neurons are distributed in two ganglionated plexuses, myenteric and submucosal, located within the walls of the stomach and intestines. Regulates the function of the digestive tract by integrating motility, secretions, blood flow, and immune responses through neural reflexes. Discuss, in general terms, how peristalsis is mediated. Peristaltic reflex motility pattern consists of propulsive segments linked to receiving segments. Parasympathetic (motility and secretion by activating myenteric & submucosal ganglion neurons) Extrinsic pathways also convey sensory information to the cns that. Give rise to both painful and non-painful sensations. Controls contraction and relaxation of gi smooth muscle. React to distension and chemical signals in the gut lumen by releasing serotonin. 5-ht activates intrinsic primary afferent neurons through 5-ht3 receptor activation.
