HIS108 Lecture Notes - Lecture 3: In Situ Hybridization, Heterochromatin, Dna Microarray
Document Summary
Biology 1a03 theme 3 module 3 and 4. Chromatin remodeling: chromatin must unravel in order for transcription to occur, dna tightly wound around a complex of histone proteins, forming the nucleosome structure, nucleosome contains an octamer of 8 histone proteins around which approximately 150. Dna base pairs wrap around: begins when an activator protein or transcription factor is able to bind to an accessible enhancer site, leading to the further recruitment of other proteins that can lead to further chromatin remodeling. Note: transcription factors are important and contribute to rna polymerase recruitment and initiation of transcription. Note: dna site bound by regulatory transcriptions factors are cis acting factors. Note: enhancer sequences may be quite distant from the promoter, however they are still. 2 efficient at recruiting rna polymerase to the promoter. Small regulatory rna: microrna molecules often form hairpin loops, proceed into smaller, single stranded mrna fragments that can then activate the.
