BIOL 1010U Lecture Notes - Flow Cytometry, Endocytosis, Endosome
Document Summary
T cells recognize ag using receptors similar to ab molecules. Recognizes ag as a complex associated with mhc (polymorphic) Optimal ab response needs b cells and t cells. Helper t cells (th) -activate b cells to make ab. Cytolycic t cells (tc)- kill infected cells and tumor cells. Ag receptors distributed on t cells in a clonal fashion, ag stimulates activation and clonal expansion. T cells develop in the thymus, (derived from bone marrow pluripotential hematopoietic stem cells) T cells see antigenic determinants = short stretches of linear sequence (10 aa) =epitope. Recall: b cell ab recognize conformational determinants lost in denaturation. T cells recognize ags only on the surface of other cells. T cells don"t recognize free antigen, has to be presented on the surface of apc (ex: macrophage, T cells from someone for a given ag cant recognize the ag on an apc from someone else b/c of mhc.
