HLSC 2110U Lecture 2: Study Notes - Lecture 2
2 Feb 2019
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Document Summary
Linear sequence of linked amino acids contains the info necessary to generate a protein with a unique shape. Determines the remaining structural features (amino acids contained determine chemical features) Any alterations in sequence may result in improper folding or impairment of function can lead to a genetic disorder. Amino acids are joined covalently by peptide bonds. Amide linkages between alpha-carboxyl group of one amino acid and the amino group of another amino acid. Denaturation by heating or high urea concentration doesn"t break peptide bonds. Can be hydrolyzed non-enzymatically on prolonged exposure to a strong acid or base at high temperatures. Free amino end (n-terminal) is written to the left and the free carboxyl end (c- terminal) to the right. All amino acid sequences are read from n-terminal to c-terminal. A tri-peptide composed of a n-terminal valine, glycine, c-terminal leucine: valylglycylleucine. Multiple amino acids linked by peptide bonds = polypeptide.
