ANP 1107 Lecture Notes - Lecture 20: Corpus Luteum, Granulosa Cell, Theca

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Jackie Carnegie

Document Summary

Ovulation ballooning ovary wall ruptures and expels secondary oocyte into the peritoneal cavity. Fsh and lh stimulate follicles to grow, matures, and secrete sex hormones. Fsh effects granulosa cells of late secondary and vesicular follicles; lh prods theca cells to release androgens: both diffuse through basement membrane where granulosa cells convert them to estrogen. Estrogen levels in plasma rise exerting negative feedback on hypothalamus and anterior pituitary, inhibiting release of gnrh (and fsh and lh) Inhibin released by granulosa cells also exert negative feedback controls on fsh release during this period: only dominant follicle survives this dip in fsh, others deteriorate, high estrogen produced by dominant follicle stimulates positive feedback of gnrh release. Lh surge triggers ovulation and formation of corpus luteum. The uterine (menstrual) cycle series of cyclic changes that the uterine endometrium goes through each month as it responds to the waxing and waning of ovarian hormones in the blood.